48.9 million
Estimated sepsis cases worldwide in 2017.
The Challenge
Sepsis Can Progress Before the Clinical Picture Is Clear
Early sepsis may resemble many other inflammatory and infectious conditions, making timely recognition difficult.
As the patient’s condition evolves, the opportunity for earlier assessment and intervention can narrow quickly.
The Global Burden
Sepsis Is a Global Medical Emergency
Sepsis occurs when the body's response to infection causes life-threatening organ dysfunction. Its impact spans hospitals, communities, and every age group.
11 million
Estimated sepsis-related deaths worldwide in 2017.
Nearly 1 in 5
Of all deaths worldwide were sepsis-related in 2017.
Global estimates for 2017, published in 2020; not a current-year count. Source: Global Burden of Disease study, The Lancet. Definition: WHO.
High-Risk Populations
Some Patients Are Especially Vulnerable
Anyone with an infection can develop sepsis. The need for timely recognition is particularly acute in these populations.
Hospital and ICU Patients
Hospitalized patients, especially those in intensive care, are among the groups at higher risk of sepsis.
People With Weakened Immunity
People with cancer or other conditions that weaken immunity, and those taking immune-suppressing medicines, face increased risk.
Newborns and Premature Babies
Newborns are vulnerable to sepsis. Premature babies face additional risk because their immune systems are still immature.
Patients With Severe Burns
Loss of the skin's protective barrier increases vulnerability to infection. The inflammatory response to major burns can also make sepsis harder to recognize.
Older Adults and Chronic Illness
Older adults and people living with conditions such as kidney or liver disease are at higher risk of sepsis.
Patients With Severe Infections
Critical illness from COVID-19 and other infectious diseases can increase the risk of developing and dying from sepsis, including during infectious disease outbreaks.
Why Recognition Is Difficult
A Dynamic Condition Without a Single Early Sign
Nonspecific Presentation
Early symptoms can overlap with many other conditions and may not immediately indicate sepsis.
Rapid Progression
A patient’s condition can change quickly, making sepsis a moving clinical target rather than a single event.
Later Clinical Recognition
Conventional warning signs may become clearer only after significant physiological changes are underway.